Doctors info

Professional Overview

Dr. Tapas Patra, Ph.D., is a Scientist and Principal Investigator in the Department of Molecular Oncology at Sri Shankara Cancer Hospital & Research Centre, Bangalore. With a Ph.D. in Molecular Immunology from ICMR–National Institute for Research in Bacterial Infection (under Jadavpur University), Kolkata, he brings over 13 years of rich research experience across premier institutions in India and the USA. His distinguished career includes key positions at the National Institute of Pathology, IISER Mohali, Chittaranjan National Cancer Institute, and Saint Louis University, where he significantly advanced molecular and translational cancer research.

Dr. Patra’s expertise spans immuno-oncology, cancer metabolism, immunotherapy, and chemo-resistance, with a strong focus on gastrointestinal-hepatobiliary cancers and platinum resistance in ovarian cancer. His work explores the immunological and molecular mechanisms driving cancer initiation and progression, contributing to innovative therapeutic strategies. He also holds a patent for a Hepatitis C virus mRNA vaccine and has made impactful contributions to COVID-19 research, including studies referenced in international treatment discussions. With 28 peer-reviewed publications in high-impact journals—many as corresponding or co-first author—he has established himself as a leading voice in translational oncology.

An active academician and scientific leader, Dr. Patra serves on the editorial boards of multiple reputed international journals and is a life member of several prestigious scientific societies, including the Indian Immunology Society and the Indian Science Congress Association. Fluent in English, Hindi, and Bengali, he is available for consultations and research collaborations from Monday to Saturday (9:00 am to 6:00 pm) at the 1st Floor, Sharada Krupa Building. Guided by a vision to achieve breakthrough discoveries that directly benefit cancer patients, Dr. Patra remains deeply committed to advancing precision oncology and improving patient outcomes.

Research Publications

1. A comparative analysis indicates SLC7A11 expression regulate the prognostic value of KEAP1-NFE2L2-CUL3 mutations in human uterine corpus endometrial carcinoma

Authors: Namani A, Veeraiyan D, Patra T

Journal: Free Radical Biology and Medicine

Published: 2024 Sep 1

Additional Details: 222:223-8

2. NRF2 signaling pathway in chemo/radio/immuno-therapy resistance of lung cancer: Looking beyond the tip of the iceberg

Authors: Ramisetti SV, Patra T, Munirathnam V, Sainath JV, Veeraiyan D, Namani A

Journal: Archivos de Bronconeumología

Published: 2024 Jul 15

3. Glyoxylate supplementation ameliorates colitis associated colon cancer progression

Authors: Murmu N, Ghosh P, Namani A, Patra T

Journal: Journal of Cellular Physiology.:e31394

4. Hepatitis C virus E1 and modified E2 delivered from an mRNA vaccine induces protective immunity

Authors: Patra T, Meyer K, Haga Y, Reagan EK, Weissman D, Ray R

Journal: NPJ vaccines

Published: 2023

Additional Details: 8(1):42

5. Targeting Lin28 axis enhances glypican-3-CAR T cell efficacy against hepatic tumor initiating cell population

Authors: Patra T, Cunningham DM, Meyer K, Toth K, Ray RB, Heczey A, et al

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: 2023

Additional Details: 31(3):715-28

6. Modified E2 Glycoprotein of Hepatitis C Virus Enhances Proinflammatory Cytokines and Protective Immune Response

Authors: Vijayamahantesh V, Patra T, Meyer K, Alameh MG, Reagan EK, Weissman D, et al

Journal: Journal of virology

Published: 2022

Additional Details: 96(12):e0052322

7. Bystander effect of SARS-CoV-2 spike protein on human monocytic THP-1 cell activation and initiation of prothrombogenic stimulus representing severe COVID-19

Authors: Patra T, Ray R

Journal: Journal of inflammation (London, England)

Published: 2022

Additional Details: 19(1):28

8. Sub-chronic cadmium and lead compound exposure induces reproductive toxicity and development of testicular germ cell neoplasia in situ in murine model: Attenuative effects of resveratrol

Authors: Mitra S, Patra T, Saha D, Ghosh P, Mustafi SM, Varghese AC, et al

Journal: Journal of biochemical and molecular toxicology

Published: 2022

Additional Details: 36(7):e23058

9. IL-6 Induction and Signaling: Horizons of COVID-19-Related Pathogenesis

Authors: Patra T, Ray R

Journal: DNA and cell biology

Published: 2021

Additional Details: 40(5):639-42

10. Akt inhibitor augments anti-proliferative efficacy of a dual mTORC1/2 inhibitor by FOXO3a activation in p53 mutated hepatocarcinoma cells

Authors: Patra T, Meyer K, Ray RB, Kanda T, Ray R

Journal: Cell death & disease

Published: 2021

Additional Details: 12(11):1073

11. Inhibition of p70 isoforms of S6K1 induces anoikis to prevent transformed human hepatocyte growth

Authors: Patra T, Bose SK, Kwon YC, Meyer K, Ray R

Journal: Life sciences

Published: 2021

Additional Details: 265:118764

12. SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells

Authors: Meyer K, Patra T, Vijayamahantesh, Ray R

Journal: Journal of virology

Published: 2021

Additional Details: 95(17):e0079421

13. Hepatitis C Virus Mediated Inhibition of miR-181c Activates ATM Signaling and Promotes Hepatocyte Growth

Authors: Patra T, Meyer K, Ray RB, Ray R

Journal: Hepatology (Baltimore, Md)

Published: 2020

Additional Details: 71(3):780-93

14. A combination of AZD5363 and FH5363 induces lethal autophagy in transformed hepatocytes

Authors: Patra T, Meyer K, Ray RB, Ray R

Journal: Cell death & disease

Published: 2020

Additional Details: 11(7):540

15. SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

Authors: Patra T, Meyer K, Geerling L, Isbell TS, Hoft DF, Brien J, et al

Journal: PLoS pathogens

Published: 2020

Additional Details: 16(12):e1009128

16. Establishment of a Patient-Derived Xenograft Tumor From Hepatitis C-Associated Liver Cancer and Evaluation of Imatinib Treatment Efficacy

Authors: Nazzal M, Sur S, Steele R, Khatun M, Patra T, Phillips N, et al

Journal: Hepatology (Baltimore, Md)

Published: 2020

Additional Details: 72(2):379-88

17. Transforming Growth Factor β Acts as a Regulatory Molecule for Lipogenic Pathways among Hepatitis C Virus Genotype-Specific Infections

Authors: Patra T, Sasaki R, Meyer K, Ray RB, Ray R

Journal: Journal of virology

Published: 2019

Additional Details: 93(18)

18. Strategies to Circumvent Host Innate Immune Response by Hepatitis C Virus

Authors: Patra T, Ray RB, Ray R

Journal: Cells

Published: 2019

Additional Details: 8(3)

19. A comparative analysis indicates SLC7A11 expression regulate the prognostic value of KEAP1-NFE2L2-CUL3 mutations in human Uterine Corpus Endometrial Carcinoma

Authors: Namani A, Veeraiyan DD, Patra T

Journal: Free Radical Biology and Medicine

Published: 2024 Jun 13

20. A comprehensive analysis and optimization of coal–biomass mixed fuel for sustainable power generation using the design of experiments and artificial neural network

Authors: Datta A, Gajera B, Saikia M, Patra T, Sarma AK

Journal: Clean Technologies and Environmental Policy

Published: 2025 Jun

Additional Details: 27(6):2615-28

21. Temoporfin loaded g-C3N4/CuO nanocarrier for treatment of hypoxic tumors by synergistic chemo-photodynamic therapy

Authors: Veeraiyan D, Sahu PN, Patra T, Joshi P, Sillanpää M, Nenavathu BP, Namani A, Sen A

Journal: Diamond and Related Materials

Published: 2025 Oct 1

Additional Details: 158:112607

22. Temoporfin loaded g-C3N4/CuO nanocarrier for treatment of hypoxic tumors by synergistic chemo-photodynamic therapy

Authors: Veeraiyan D, Sahu PN, Patra T, Joshi P, Sillanpää M, Nenavathu BP, Namani A, Sen A

Journal: Diamond and Related Materials

Published: 2025 Oct 1

Additional Details: 158:112607

23. Mechanisms and complexities underlying the cancer cell immune evasion and its therapeutic implications

Authors: Chi Z, Patra T, Namani A

Journal: Frontiers in Immunology

Published: 2025 Nov 25

Additional Details: 16:1747904

24. Immune infiltration in TP53 missense mutant contributes to poor prognosis in hepatocellular carcinoma, unlike CTNNB1 mutations

Authors: Veeraiyan D, Kurpad V, Munirathnam V, V C, Asthana S, Namani A, Patra T

Journal: Malignancy Spectrum

Published: 2025 Sep

Additional Details: 2(3):117-27

25. Sex-based molecular and prognostic disparities in pan-cancer: an analysis across the global cohorts

Authors: Sivakumar G, Patra T, Veeraiyan D, Namani A

Journal: Clinical and Translational Oncology

Published: 2025 Nov 17

Additional Details: 1-2

Dr. Tapas Patra

Professional Overview

Research Publications

1. A comparative analysis indicates SLC7A11 expression regulate the prognostic value of KEAP1-NFE2L2-CUL3 mutations in human uterine corpus endometrial carcinoma

2. NRF2 signaling pathway in chemo/radio/immuno-therapy resistance of lung cancer: Looking beyond the tip of the iceberg

3. Glyoxylate supplementation ameliorates colitis associated colon cancer progression

4. Hepatitis C virus E1 and modified E2 delivered from an mRNA vaccine induces protective immunity

5. Targeting Lin28 axis enhances glypican-3-CAR T cell efficacy against hepatic tumor initiating cell population

6. Modified E2 Glycoprotein of Hepatitis C Virus Enhances Proinflammatory Cytokines and Protective Immune Response

7. Bystander effect of SARS-CoV-2 spike protein on human monocytic THP-1 cell activation and initiation of prothrombogenic stimulus representing severe COVID-19

8. Sub-chronic cadmium and lead compound exposure induces reproductive toxicity and development of testicular germ cell neoplasia in situ in murine model: Attenuative effects of resveratrol

9. IL-6 Induction and Signaling: Horizons of COVID-19-Related Pathogenesis

10. Akt inhibitor augments anti-proliferative efficacy of a dual mTORC1/2 inhibitor by FOXO3a activation in p53 mutated hepatocarcinoma cells

11. Inhibition of p70 isoforms of S6K1 induces anoikis to prevent transformed human hepatocyte growth

12. SARS-CoV-2 Spike Protein Induces Paracrine Senescence and Leukocyte Adhesion in Endothelial Cells

13. Hepatitis C Virus Mediated Inhibition of miR-181c Activates ATM Signaling and Promotes Hepatocyte Growth

14. A combination of AZD5363 and FH5363 induces lethal autophagy in transformed hepatocytes

15. SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

16. Establishment of a Patient-Derived Xenograft Tumor From Hepatitis C-Associated Liver Cancer and Evaluation of Imatinib Treatment Efficacy

17. Transforming Growth Factor β Acts as a Regulatory Molecule for Lipogenic Pathways among Hepatitis C Virus Genotype-Specific Infections

18. Strategies to Circumvent Host Innate Immune Response by Hepatitis C Virus

19. A comparative analysis indicates SLC7A11 expression regulate the prognostic value of KEAP1-NFE2L2-CUL3 mutations in human Uterine Corpus Endometrial Carcinoma

20. A comprehensive analysis and optimization of coal–biomass mixed fuel for sustainable power generation using the design of experiments and artificial neural network

21. Temoporfin loaded g-C3N4/CuO nanocarrier for treatment of hypoxic tumors by synergistic chemo-photodynamic therapy

22. Temoporfin loaded g-C3N4/CuO nanocarrier for treatment of hypoxic tumors by synergistic chemo-photodynamic therapy

23. Mechanisms and complexities underlying the cancer cell immune evasion and its therapeutic implications

24. Immune infiltration in TP53 missense mutant contributes to poor prognosis in hepatocellular carcinoma, unlike CTNNB1 mutations

25. Sex-based molecular and prognostic disparities in pan-cancer: an analysis across the global cohorts

Languages Spoken

Request Discussion with Dr. Tapas Patra (Molecular Diagnostics & Research)