Dr Sreekala | Research Scientist in Bengaluru | Sri Shankara Cancer Hospital & Research Centre
Dr. Sreekala

Dr. Sreekala

Ph.D – St. John’s National Academy of Health Sciences, Bengaluru

Post Doctoral Scientist

M.Sc – Biochemistry

17 years of experience
Book Consultation

Professional Overview

Dr. Sreekala obtained her Master’s degree in Biochemistry from Maharani Lakshmi Ammanni College for Women, Bangalore University. After completion of M.Sc, she joined as a Project Assistant in the Clinical Proteomics laboratory at St. John’s Research Institute (SJRI), Bangalore. During her tenure in SJRI, she was trained in various analytical techniques like Column Chromatography, HPLC, and high-end instruments like MALDI AND ESI-Mass Spectrometry. She received experience in employing different types of Mass Spectrometers like Q-TOF and Triple Quad for various projects.

She pursued her Doctoral degree under Dr. Amit Kumar Mandal from Rajiv Gandhi University of Health Sciences for the thesis entitled “Structure and function analysis of glutathionylated and glycated conjugates of commonly occurring Hemoglobin variants in India: HbE, HbD and HbA2”. Currently she is working as a Senior Research Associate in the Department of Molecular Oncology at Sri Shankara Cancer Hospital and Research Centre. She is in-charge of the Mass Spectrometry facility in the department and is involved in many research projects involving mass spectrometry platform. She is actively involved in monitoring the activities of the Biobank and also in the development of a LIMS software for the Biobank facility in the department. Her research interests include Breast cancer, Head & Neck cancer, Hematological malignancies, Proteomics, Metabolomics.

PostDoc / Experience

  • Working as a Senior Research Associate at the Department of Molecular Oncology at Sri Shankara Cancer Hospital and Research Centre.

Research Area / Interest

  • Breast cancer
  • Head & Neck cancer
  • Hematological malignancies
  • Proteomics
  • Metabolomics

Research

  • Understanding the mechanism of radiation resistance in Head and Neck Squamous cell carcinomas

Research Publications

1. Effect of point mutation on structure-function correlation of hemoglobin variants, HbE and HbD Punjab

Authors: Sreekala Narayanan, Boby Mathew, Bindu Y Srinivasu, Vijay Bhat, Cecil Ross, Amit Kumar Mandal

Journal: Amino Acids

Published: 2020

Additional Details: 52 (6-7): 893-904

2. Functional prediction from conformational dynamics of glycated and glutathionylated HbE and HbD Punjab

Authors: Sreekala Narayanan, Boby Mathew, Bindu Y Srinivasu, Monita Muralidharan, Vijay Bhat, Cecil Ross, Amit Kumar Mandal

Journal: Current Science

Published: 2020

Additional Details: 118 (5): 722-727

3. Analysis of Isotopic Peaks in Hydrogen/Deuterium Exchange Mass Spectra for Precise Measurement of Isotope Average Centroid Mass of Peptides and Proteins using R Programming Language

Authors: Arumugaperumal Arun, Sreekala Narayanan, Subhasis Sarangi, Amit Kumar Mandal

Journal: International Journal of Biochemistry Research and Review

Published: 2017

Additional Details: 18 (3): 1-8

4. Protein Structure–Function Correlation in Living Human Red Blood Cells Probed by Isotope Exchange–Based Mass Spectrometry

Authors: Sreekala Narayanan, Gopa Mitra, Monita Muralidharan, Boby Mathew, Amit Kumar Mandal

Journal: Analytical Chemistry

Published: 2015

Additional Details: 87 (23): 11813-11818

5. Glutathionylation Induced Structural Changes in Oxy Human Hemoglobin Analyzed by Backbone Amide Hydrogen/Deuterium Exchange and MALDI-Mass Spectrometry

Authors: Gopa Mitra, Monita Muralidharan, Sreekala Narayanan, Jennifer Pinto, Krishnamachari Srinivasan, Amit Kumar Mandal

Journal: Bioconjugate Chemistry

Published: 2012

Additional Details: 23 (12): 2344-2353

Projects

Sl. No. Project Title Source of Funds Duration Role Status
1 A Proteomic Investigation to Discover Candidate Proteins Involved in Mechanisms of Radiation Resistance in Head and Neck Squamous Cell cancers. RGUHS 2024–2026 Co-PI Ongoing

Languages Spoken

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