Dr. Akhileshwar Namani | Research Scientist in Bengaluru | Sri Shankara Cancer Hospital & Research Centre
Dr. Akhileshwar Namani

Dr. Akhileshwar Namani

Scientist

Molecular Oncology, Specialty : Cancer biology, Oxidative stress, Biomedical Genomics

8 years (Post PhD), 14 years (Post MSc)

PhD - Biochemistry and Molecular Biology

Book Consultation

Professional Overview

Dr. Akhileshwar Namani is working as a Scientist in the Department of Molecular Oncology at Sri Shankara Cancer Hospital and Research Centre (SSCHRC) and the Sri Shankara National Centre for Cancer Prevention and Research (SSNCCPR) in Bengaluru, India. Specializing in biomedical genomics, cancer bioinformatics, and multi-omics research, his work bridges computational biology with translational oncology. His research primarily focuses on deciphering the molecular mechanisms of cancer progression and therapeutic resistance, biomarker discovery, and drug discovery. Dr. Namani earned his Ph.D. in Biochemistry and Molecular Biology from Zhejiang University School of Medicine (THE world rank #47) in 2017, supported by a prestigious international scholarship from the China Scholarship Council. He later completed a two-year postdoctoral fellowship at the same institution before serving as an Assistant Professor in the Department of Biotechnology at GITAM University from 2020 to 2022.

Over his career, he has built a strong scholarly footprint with over 23 peer-reviewed publications in reputable peer reviewed high impact journals, accumulating more than 2,900 citations with an H-index of 13. He is the Principal Investigator and Co-Principal Investigator of major national research grants from agencies like the Indian Council of Medical Research (ICMR) and the Anusandhan National Research Foundation (ANRF). In addition to his research activities, Dr. Namani is serving on the editorial boards of Phenomics, BMC Cancer, Discover Oncology, and Discover Medicine (Springer Nature journals), acting as an expert reviewer of >30 journals, and frequently presenting as an invited speaker and key opinion leader at oncology and molecular pathology conclaves. He is an active member of leading global oncology societies, including the European Society for Medical Oncology and the International Association for the Study of Lung Cancer.2

Grants

1. Role of NRF2-regulated UDP-glucuronosyltransferases (UGTs) in chemoresistance of lung cancer and identification of FDA-approved drugs for NRF2/UGTs inhibition.
Role: Principal Investigator
Funding Agency: Anusandhan National Research Foundation (ANRF) under Prime Minister Early Career Research Grant Scheme
Duration: 3 years (2025–2028)

2. A cost-effective and minimally invasive liquid biopsy: Utilizing fine-needle aspiration supernatants for molecular profiling and precision oncology in lung cancer diagnosis.
Role: Principal Investigator
Funding Agency: Indian Council of Medical Research (ICMR)
Duration: 3 years (2025–2028)

3. Epigenetic Modulation of ATAD2 Bromodomain: A Precision Therapeutics Approach for Patient-Centric Cancer Treatment in Head and Neck Malignancy.
Role: Co-Principal Investigator
Funding Agency: Indian Council of Medical Research (ICMR)
Duration: 3 years (2025–2028)

4. Dissecting the immune landscape of EGFR mutant lung cancers: A transcriptomic study of immune cold tumors.
Role: Co-Principal Investigator
Funding Agency: Rajiv Gandhi University of Health Sciences (RGUHS)
Duration: 2 years (2026–2028)

Research Publications

1. Prosthetic Rehabilitation of Velopharyngeal Insufficiency in a Patient with Locally Advanced Carcinoma Oropharynx: A Case Report

Authors: Jyothi Venkat Sainath, Akhileshwar Namani, Vinayak Munirathnam, Karthik Rishi

Journal: Proceedings of The 1st International Online Conference on Prosthesis

Published: 2025 Dec 5

Additional Details: The 1st International Online Conference on Prosthesis, 10–12 December 2025 | MDPI | SciForum Paper 28224

2. Mechanisms and complexities underlying the cancer cell immune evasion and its therapeutic implications

Authors: Chi Z, Patra T, Namani A

Journal: Frontiers in Immunology

Published: 2025 Nov 25

Additional Details: 16:1747904

3. Sex-based molecular and prognostic disparities in pan-cancer: an analysis across the global cohorts

Authors: Sivakumar G, Patra T, Veeraiyan D, Namani A

Journal: Clinical and Translational Oncology

Published: 2025 Nov 17

Additional Details: 1-2

4. Temoporfin loaded g-C3N4/CuO nanocarrier for treatment of hypoxic tumors by synergistic chemo-photodynamic therapy

Authors: Veeraiyan D, Sahu PN, Patra T, Joshi P, Sillanpää M, Nenavathu BP, Namani A, Sen A

Journal: Diamond and Related Materials

Published: 2025 Oct 1

Additional Details: 158:112607

5 Immune infiltration in TP53 missense mutant contributes to poor prognosis in hepatocellular carcinoma, unlike CTNNB1 mutations

Authors: Veeraiyan D, Kurpad V, Munirathnam V, V C, Asthana S, Namani A, Patra T

Journal: Malignancy Spectrum

Published: 2025 Sep

Additional Details: 2(3):117-27

6. Management of Endocrine-Resistant, Recurrent Metastatic Hormone Receptor-Positive Breast Cancer: A Case Report

Authors: Vinayak Munirathnam, Thapashwi B G, Tapas Patra, Akhileshwar Namani

Journal: Proceedings of The 1st International Online Conference on Clinical Reports

Published: 2025 Mar 17

Additional Details: The 1st International Online Conference on Clinical Reports, 19–20 March 2025 | MDPI | SciForum Paper 21513

7. Adjuvant Nivolumab for Residual Disease Post-Neoadjuvant Chemoradiation and Surgery for Esophageal Squamous Cell Carcinoma—Are We There Yet?

Authors: Sreevalli A, Sanjeev Kulkarni, Akhileshwar Namani, B S Srinath

Journal: Proceedings of the 1st International Online Conference on Clinical Reports

Published: 2025 Mar 17

Additional Details: 1st International Online Conference on Clinical Reports, 19–20 March 2025 | MDPI | SciForum Paper 21511

8. Glyoxylate supplementation ameliorates colitis associated colon cancer progression

Authors: Murmu N, Ghosh P, Namani A, Patra T

Journal: Journal of Cellular Physiology

Published: 2024 Sep 5

Additional Details: Volume 239, Issue 11, Article e31394 | DOI: 10.1002/jcp.31394 | PMID: 39238268

9. A comparative analysis indicates SLC7A11 expression regulate the prognostic value of KEAP1-NFE2L2-CUL3 mutations in human uterine corpus endometrial carcinoma

Authors: Namani A, Veeraiyan D, Patra T

Journal: Free Radical Biology and Medicine

Published: 2024 Sep 1

Additional Details: 222:223–228 | DOI: 10.1016/j.freeradbiomed.2024.06.008 | PMID: 38876457

10. NRF2 signaling pathway in chemo/radio/immuno-therapy resistance of lung cancer: Looking beyond the tip of the iceberg

Authors: Ramisetti SV, Patra T, Munirathnam V, Sainath JV, Veeraiyan D, Namani A

Journal: Archivos de Bronconeumología

Published: 2024 Jul 15

Additional Details: Volume 60, Supplement 2, Pages S59–S66 | DOI: 10.1016/j.arbres.2024.06.021 | PMID: 39060123

11. NRF2 has a splicing regulatory function involving the survival of motor neuron (SMN) in non-small cell lung cancer

Authors: Cui Q, Wang W, Namani A, Wang H, Hammad A, Huang P, et al

Journal: Oncogene

Published: 2023

Additional Details: 42(37):2751-63

12. Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice

Authors: Hammad A, Zheng ZH, Namani A, Elshaer M, Wang XJ, Tang X

Journal: BMC cancer

Published: 2021

Additional Details: 21(1):607

13. Integrated data analysis reveals significant associations of KEAP1 mutations with DNA methylation alterations in lung adenocarcinomas

Authors: Elshaer M, ElManawy AI, Hammad A, Namani A, Wang XJ, Tang X

Journal: Aging

Published: 2020

Additional Details: 12(8):7183-206

14. Comparative transcriptome analysis reveals Dusp1 as a critical regulator of inflammatory response to fly ash particle exposure in mouse

Authors: Zhang J, Chen Y, Namani A, Elshaer M, Jiang Z, Shi H, et al

Journal: Ecotoxicology and environmental safety

Published: 2020

Additional Details: 190:110116

15. Transcriptomic profiling identifies a critical role of Nrf2 in regulating the inflammatory response to fly ash particles in mouse lung

Authors: Zhang J, Cui H, Namani A, Yao J, Deng H, Tang X, et al

Journal: Ecotoxicology and environmental safety

Published: 2020

Additional Details: 190:110132

16. "NRF2 addiction" in lung cancer cells and its impact on cancer therapy

Authors: Hammad A, Namani A, Elshaer M, Wang XJ, Tang X

Journal: Cancer letters

Published: 2019

Additional Details: 467:40-9

17. Identification of novel Nrf2 target genes as prognostic biomarkers in colitis-associated colorectal cancer in Nrf2-deficient mice

Authors: Hammad A, Zheng ZH, Gao Y, Namani A, Shi HF, Tang X

Journal: Life sciences

Published: 2019

Additional Details: 238:116968

18. Genome-wide global identification of NRF2 binding sites in A549 non-small cell lung cancer cells by ChIP-Seq reveals NRF2 regulation of genes involved in focal adhesion pathways

Authors: Namani A, Liu K, Wang S, Zhou X, Liao Y, Wang H, et al

Journal: Aging

Published: 2019

Additional Details: 11(24):12600-23

19. Systematic Identification of Multi Omics-based Biomarkers in KEAP1 Mutated TCGA Lung Adenocarcinoma

Authors: Namani A, Zheng Z, Wang XJ, Tang X

Journal: Journal of Cancer

Published: 2019

Additional Details: 10(27):6813-21

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